Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis

20041,493 citationsJournal Article

Authors

Timothy R. Chan · Scripps Research Institute

Robert Hilgraf · Scripps Research Institute

K. Barry Sharpless · Scripps Research Institute

Valery V. Fokin · Scripps Research Institute

Abstract

Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes. The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.

Topics & Keywords

Click Chemistry and Applications Chemical Synthesis and Analysis Advanced biosensing and bioanalysis techniques

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Organic Letters

Volume 6, Issue 17, pp. 2853-2855

DOI: 10.1021/ol0493094

Field-Weighted Citation Impact: 23.93