Immune surveillance in multiple sclerosis patients treated with natalizumab

2006434 citationsJournal Articlebronze Open Access

Authors

Olaf Stüve · Heinrich Heine University Düsseldorf

Christina M. Marra · University of Washington

Keith R. Jerome · Heinrich Heine University Düsseldorf

Linda Cook · Fred Hutch Cancer Center

Petra D. Cravens · The University of Texas Southwestern Medical Center

Sabine Cepok · Heinrich Heine University Düsseldorf

Elliot M. Frohman

Abstract

These data suggest that natalizumab treatment results in a prolonged decrease of lymphocytes in the CSF and are consistent with the hypothesis that natalizumab impairs immune surveillance of the central nervous system.

Topics & Keywords

Polyomavirus and related diseases Multiple Sclerosis Research Studies Full-Duplex Wireless Communications

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Annals of Neurology

Volume 59, Issue 5, pp. 743-747

DOI: 10.1002/ana.20858

Field-Weighted Citation Impact: 15.01