Metastatic tumor evolution and organoid modeling implicate TGFBR2as a cancer driver in diffuse gastric cancer

2014133 citationsJournal Articlegold Open Access

Authors

Lincoln Nadauld · Stanford University

Sarah Garcia · Stanford University

Georges Natsoulis · Stanford University

John Bell · Stanford University

Laura Miotke · Stanford University

Erik Hopmans · Stanford University

Hua Xu · Stanford University

Abstract

We document the metastatic differentiation and genetic heterogeneity of diffuse gastric cancer and reveal the potential metastatic role of TGFBR2 loss-of-function. In support of this study, we apply a murine primary organoid culture method capable of recapitulating in vivo metastatic gastric cancer. Overall, we describe an integrated approach to identify and functionally validate putative cancer drivers involved in metastasis.

Topics & Keywords

Cancer Genomics and Diagnostics TGF-β signaling in diseases Genetic factors in colorectal cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Genome biology

Volume 15, Issue 8, pp. 428-428

DOI: 10.1186/s13059-014-0428-9

Field-Weighted Citation Impact: 4.99