Trial of Early, Goal-Directed Resuscitation for Septic Shock

20151,582 citationsJournal Articlebronze Open Access

Authors

Paul Mouncey · Intensive Care National Audit & Research Centre

Tiffany M. Osborn · Washington University in St. Louis

G. Sarah Power · Intensive Care National Audit & Research Centre

David A Harrison · Intensive Care National Audit & Research Centre

Zia Sadique · London School of Hygiene & Tropical Medicine

Richard Grieve · London School of Hygiene & Tropical Medicine

Rahi Jahan

Abstract

In patients with septic shock who were identified early and received intravenous antibiotics and adequate fluid resuscitation, hemodynamic management according to a strict EGDT protocol did not lead to an improvement in outcome. (Funded by the United Kingdom National Institute for Health Research Health Technology Assessment Programme; ProMISe Current Controlled Trials number, ISRCTN36307479.).

Topics & Keywords

Sepsis Diagnosis and Treatment Cardiac Arrest and Resuscitation Intensive Care Unit Cognitive Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 372, Issue 14, pp. 1301-1311

DOI: 10.1056/nejmoa1500896

Field-Weighted Citation Impact: 161.38