Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease

20091,605 citationsJournal Articlebronze Open Access

Authors

Robert Clarke · University of Oxford

John F. Peden · University of Oxford

Jemma C. Hopewell · University of Oxford

Theodosios Kyriakou · University of Oxford

Anuj Goel · University of Oxford

Simon Heath

Sarah Parish · University of Oxford

Abstract

We identified two LPA variants that were strongly associated with both an increased level of Lp(a) lipoprotein and an increased risk of coronary disease. Our findings provide support for a causal role of Lp(a) lipoprotein in coronary disease.

Topics & Keywords

Lipoproteins and Cardiovascular Health Atherosclerosis and Cardiovascular Diseases Peroxisome Proliferator-Activated Receptors

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 26, pp. 2518-2528

DOI: 10.1056/nejmoa0902604

Field-Weighted Citation Impact: 63.61