Modulation of Age- and Cancer-Associated DNA Methylation Change in the Healthy Colon by Aspirin and Lifestyle

201483 citationsJournal Articlehybrid Open Access

Authors

Faiza Noreen · University of Basel

Martin Röösli · Swiss Tropical and Public Health Institute

Paweł Gaj · The Maria Sklodowska-Curie National Research Institute of Oncology

Jakub Pietrzak

Stefan Weis · University of Basel

Patric Urfer · University of Basel

Jarosław Reguła · University of Basel

Abstract

Lifestyle, including aspirin use, modulates age-associated DNA methylation change in the colonic epithelium and thereby impacts the evolution of cancer methylomes.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genetic Syndromes and Imprinting

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 106, Issue 7

DOI: 10.1093/jnci/dju161

Field-Weighted Citation Impact: 4.26