Living Autologous Heart Valves Engineered From Human Prenatally Harvested Progenitors

2006145 citationsJournal Article

Authors

Dörthe Schmidt · University Hospital of Zurich

Anita Mol · Sophia Genetics (Switzerland)

Christian Breymann · Eindhoven University of Technology

Josef Achermann · Hirslanden Private Hospital Group

Bernhard Odermatt · University Hospital of Zurich

Matthias Gössi · Eindhoven University of Technology

Stefan Neuenschwander

Abstract

Prenatal fetal progenitors obtained from routine chorionic villus sampling were successfully used as an exclusive, new cell source for the engineering of living heart valve leaflets. This concept may enable autologous replacements with growth potential ready for use at birth. Combined with the use of cell banking technology, this approach may be applied also for postnatal applications.

Topics & Keywords

Tissue Engineering and Regenerative Medicine Electrospun Nanofibers in Biomedical Applications Congenital Heart Disease Studies

Publication Details

Published in: Circulation

Volume 114, Issue 1_supplement, pp. I125-31

DOI: 10.1161/circulationaha.105.001040

Field-Weighted Citation Impact: 10.55

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Living Autologous Heart Valves Engineered From Human Prenatally Harvested Progenitors

Authors

Abstract

Topics & Keywords

Publication Details