Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy

20091,695 citationsJournal Article

Authors

Denis Azzopardi · Imperial College London

Brenda Strohm · University of Oxford

A. David Edwards · Imperial College London

Leigh Dyet · Imperial College London

Henry L. Halliday · Queen's University Belfast

Edmund Juszczak · University of Oxford

Olga Kapellou ·

Abstract

Induction of moderate hypothermia for 72 hours in infants who had perinatal asphyxia did not significantly reduce the combined rate of death or severe disability but resulted in improved neurologic outcomes in survivors. (Current Controlled Trials number, ISRCTN89547571.)

Topics & Keywords

Neonatal and fetal brain pathology Neonatal Respiratory Health Research Neuroscience of respiration and sleep

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 361, Issue 14, pp. 1349-1358

DOI: 10.1056/nejmoa0900854

Field-Weighted Citation Impact: 161.95