Significant Association of Oncogene YAP1 with Poor Prognosis and Cetuximab Resistance in Colorectal Cancer Patients

2014161 citationsJournal Articlebronze Open Access

Authors

Keun‐Wook Lee · The University of Texas MD Anderson Cancer Center

Sung Sook Lee · The University of Texas MD Anderson Cancer Center

Sang-Bae Kim · The University of Texas MD Anderson Cancer Center

Bo Hwa Sohn · The University of Texas MD Anderson Cancer Center

Hyun‐Sung Lee · The University of Texas MD Anderson Cancer Center

Hee-Jin Jang · The University of Texas MD Anderson Cancer Center

Abstract

Activation of YAP1 is highly associated with poor prognosis for colorectal cancer and may be useful in identifying patients with metastatic colorectal cancer resistant to cetuximab.

Topics & Keywords

Hippo pathway signaling and YAP/TAZ

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 21, Issue 2, pp. 357-364

DOI: 10.1158/1078-0432.ccr-14-1374

Field-Weighted Citation Impact: 6.53