Performance of Common Genetic Variants in Breast-Cancer Risk Models

2010411 citationsJournal Articlebronze Open Access

Authors

Sholom Wacholder · National Cancer Institute

Patricia Hartge · Information Management Services

Ross L. Prentice · Fred Hutch Cancer Center

Montserrat García‐Closas · National Cancer Institute

Heather Spencer Feigelson · Kaiser Permanente Center for Health Research

W. Ryan Diver · American Cancer Society

Michael J. Thun

Abstract

The inclusion of newly discovered genetic factors modestly improved the performance of risk models for breast cancer. The level of predicted breast-cancer risk among most women changed little after the addition of currently available genetic information.

Topics & Keywords

BRCA gene mutations in cancer Global Cancer Incidence and Screening Nutrition, Genetics, and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 362, Issue 11, pp. 986-993

DOI: 10.1056/nejmoa0907727

Field-Weighted Citation Impact: 40.12