Prevalence and partial sequence analysis of human T cell lymphotropic virus type I in China

200526 citationsJournal Article

Authors

Youchun Wang · National Institutes for Food and Drug Control

LI Xiou-hua · National Institutes for Food and Drug Control

Aijing Song · National Institutes for Food and Drug Control

Chuntao Zhang · National Institutes for Food and Drug Control

Ying Chen · Fujian Blood Center

Changrong Chen · Xiamen Blood Center

Yi‐Sheng Lin

Abstract

A total of 145,293 serum samples were collected from volunteer blood donors in 13 provinces of China and tested for anti-HTLV antibody using an ELISA licensed in China. Thirty were positive for anti-HTLV by ELISA and 19 of those 30 samples were confirmed positive using a supplemental immunoblot assay. Anti-HTLV-I was detected only in samples from Fujian province (a Southern province) where the positivity rate was approximately 0.05%. The region encoding gp46 from 5 of the 19 antibody positive samples was amplified and sequenced. Sequence analysis indicated that these isolates belong to HTLV-I genotype A. These data suggest that HTLV-I is not endemic throughout China and the virus may be restricted to a particular region.

Topics & Keywords

T-cell and Retrovirus Studies Animal Disease Management and Epidemiology Vector-Borne Animal Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Medical Virology

Volume 76, Issue 4, pp. 613-618

DOI: 10.1002/jmv.20405

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