Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation

200475 citationsJournal Articlegold Open Access

Authors

Christina Kaiser · Swedish Orphan Biovitrum (Sweden)

Stephen R. James · Swedish Orphan Biovitrum (Sweden)

Abstract

Our results show that IRS-1 is an acetylated protein, a post-translational modification that has not been previously described. Acetylation of IRS-1 is permissive for tyrosine phosphorylation and facilitates insulin-stimulated signal transduction. Specific inhibition of HDAC2 may increase insulin sensitivity in otherwise insulin resistant conditions.

Topics & Keywords

Histone Deacetylase Inhibitors Research Ubiquitin and proteasome pathways Protein Degradation and Inhibitors

Publication Details

Published in: BMC Biology

Volume 2, Issue 1, pp. 23-23

DOI: 10.1186/1741-7007-2-23

Field-Weighted Citation Impact: 1.32

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Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation

Authors

Abstract

Topics & Keywords

Publication Details