Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia

2013203 citationsJournal Articlegreen Open Access

Authors

Elise G.P. Dopper · Sint Franciscus Gasthuis

Serge A.R.B. Rombouts · Sint Franciscus Gasthuis

Lize C. Jiskoot · Czech Academy of Sciences, Institute of Psychology

Tom den Heijer · Leiden University

J. Roos A. de Graaf · Czech Academy of Sciences, Institute of Psychology

Inge de Koning · Czech Academy of Sciences, Institute of Psychology

Anke R. Hammerschlag

Abstract

This study convincingly demonstrates that alterations in structural and functional connectivity develop before the first symptoms of FTD arise. These findings suggest that diffusion tensor imaging and resting-state fMRI may have the potential to become sensitive biomarkers for early FTD in future clinical trials.

Topics & Keywords

Advanced Neuroimaging Techniques and Applications Amyotrophic Lateral Sclerosis Research Functional Brain Connectivity Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 80, Issue 9, pp. 814-823

DOI: 10.1212/wnl.0b013e31828407bc

Field-Weighted Citation Impact: 19.60