Functional Hypofrontality and Working Memory Dysfunction in Schizophrenia

1998403 citationsJournal Article

Authors

Cameron S. Carter · University of Pittsburgh

William M. Perlstein · University of Pittsburgh

Rohan Ganguli · University of Pittsburgh

Jaspreet S. Brar · University of Pittsburgh

Mark A. Mintun · University of Pittsburgh

Jonathan D. Cohen · University of Pittsburgh

Abstract

These results confirm the importance of using tasks that tap specific cognitive functions, linked to specific neural systems, in studies of brain-behavior relationships in schizophrenia. Hypofrontality is reliably demonstrated in schizophrenia during tasks that engage working memory functions of the prefrontal cortex.

Topics & Keywords

Functional Brain Connectivity Studies Schizophrenia research and treatment Neuroscience and Music Perception

UN Sustainable Development Goals

Decent work and economic growth

Publication Details

Published in: American Journal of Psychiatry

Volume 155, Issue 9, pp. 1285-1287

DOI: 10.1176/ajp.155.9.1285

Field-Weighted Citation Impact: 8.56