Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

2008664 citationsJournal Articlebronze Open Access

Authors

Jacob M. Haus · Cleveland Clinic Lerner College of Medicine

Sangeeta R. Kashyap · Cleveland Clinic

Takhar Kasumov · Cleveland Clinic

Renliang Zhang · Cleveland Clinic

Karen R. Kelly · Case Western Reserve University

Ralph A. DeFronzo · The University of Texas Health Science Center at San Antonio

John P. Kirwan

Abstract

Plasma ceramide levels are elevated in type 2 diabetic subjects and may contribute to insulin resistance through activation of inflammatory mediators, such as TNF-alpha.

Topics & Keywords

Sphingolipid Metabolism and Signaling Lipid Membrane Structure and Behavior Regulation of Appetite and Obesity

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 58, Issue 2, pp. 337-343

DOI: 10.2337/db08-1228

Field-Weighted Citation Impact: 6.48