High Expression of <b> <i>PRL-3</i> </b> Promotes Cancer Cell Motility and Liver Metastasis in Human Colorectal Cancer

These results indicate that PRL-3 expression in colorectal cancers may contribute to the establishment of liver metastasis, particularly at the step in which cancer cells leave the circulation to extravasate into the liver tissue. In addition, PRL-3 is expected to be a promising biomarker for identifying colorectal cancer patients at high risk for distant metastases.