Comparative safety of antiepileptic drugs during pregnancy

2012614 citationsJournal Article

Authors

Sonia Hernández–Dı́az · Massachusetts Department of Public Health

C. R. Smith · Massachusetts Department of Public Health

Aizong Shen · Massachusetts Department of Public Health

Robert Mittendorf · Massachusetts Department of Public Health

W. Allen Hauser · Massachusetts Department of Public Health

M. S. Yerby · Massachusetts Department of Public Health

Lewis B. Holmes

Abstract

AEDs such as valproate and phenobarbital were associated with a higher risk of major malformations than newer AEDs such as lamotrigine and levetiracetam. Topiramate was associated with an increased risk of cleft lip compared with that of a reference population.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Pregnancy and Medication Impact Epilepsy research and treatment

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 78, Issue 21, pp. 1692-1699

DOI: 10.1212/wnl.0b013e3182574f39

Field-Weighted Citation Impact: 71.55