Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome

2014654 citationsJournal Articlebronze Open Access

Authors

Richard S. Legro · Pennsylvania State University

Robert G. Brzyski · The University of Texas Health Science Center at San Antonio

Michael P. Diamond · Augusta University

Christos Coutifaris · University of Pennsylvania

William D. Schlaff · University of Colorado Anschutz Medical Campus

Peter R. Casson · University of Vermont

Gregory M. Christman

Abstract

As compared with clomiphene, letrozole was associated with higher live-birth and ovulation rates among infertile women with the polycystic ovary syndrome. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development and others; ClinicalTrials.gov number, NCT00719186.).

Topics & Keywords

Ovarian function and disorders Reproductive Biology and Fertility Assisted Reproductive Technology and Twin Pregnancy

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: New England Journal of Medicine

Volume 371, Issue 2, pp. 119-129

DOI: 10.1056/nejmoa1313517

Field-Weighted Citation Impact: 65.00