Impairment of paravascular clearance pathways in the aging brain

20141,436 citationsJournal Articlegreen Open Access

Authors

Benjamin T. Kress · University of Rochester

Jeffrey J. Iliff · University of Rochester

Maosheng Xia · University of Rochester

Minghuan Wang · University of Rochester

Helen Wei · University of Rochester

Douglas Zeppenfeld · Oregon Health & Science University

Lulu Xie ·

Abstract

We propose that impaired glymphatic clearance contributes to cognitive decline among the elderly and may represent a novel therapeutic target for the treatment of neurodegenerative diseases associated with accumulation of misfolded protein aggregates.

Topics & Keywords

Cerebrospinal fluid and hydrocephalus Traumatic Brain Injury and Neurovascular Disturbances Advanced Neuroimaging Techniques and Applications

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Annals of Neurology

Volume 76, Issue 6, pp. 845-861

DOI: 10.1002/ana.24271

Field-Weighted Citation Impact: 23.66