Hypoxia Decreases Insulin Signaling Pathways in Adipocytes

2008276 citationsJournal Articlehybrid Open Access

Authors

Claire Regazzetti · Centre Méditerranéen de Médecine Moléculaire

Pascal Peraldi · Centre National de la Recherche Scientifique

Thierry Grémeaux · Centre Méditerranéen de Médecine Moléculaire

Rosanna Najem-Lendom · Centre Méditerranéen de Médecine Moléculaire

Issam Ben‐Sahra · Université Côte d'Azur

Mireille Cormont · Inserm

Frédéric Bost

Abstract

We have demonstrated that hypoxia creates a state of insulin resistance in adipocytes that is dependent upon HIF transcription factor expression. Hypoxia could be envisioned as a new mechanism that participates in insulin resistance in adipose tissue of obese patients.

Topics & Keywords

Adipose Tissue and Metabolism Cancer, Hypoxia, and Metabolism Metabolism, Diabetes, and Cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 58, Issue 1, pp. 95-103

DOI: 10.2337/db08-0457

Field-Weighted Citation Impact: 7.97