Noninvasive Prenatal Detection of Fetal Trisomy 18 by Epigenetic Allelic Ratio Analysis in Maternal Plasma: Theoretical and Empirical Considerations

2006158 citationsJournal Articlebronze Open Access

Authors

Tong Yu

Chunming Ding · National Centre for Infectious Diseases

Rossa W. K. Chiu · Chinese University of Hong Kong

Ageliki Gerovassili · Harris Birthright Research Centre for Fetal Medicine

K. H. Nicolaides · Harris Birthright Research Centre for Fetal Medicine

Abstract

Epigenetic allelic ratio analysis of maternal plasma DNA represents a promising approach for noninvasive prenatal diagnosis of fetal chromosomal aneuploidies.

Topics & Keywords

Prenatal Screening and Diagnostics Epigenetics and DNA Methylation Fetal and Pediatric Neurological Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Chemistry

Volume 52, Issue 12, pp. 2194-2202

DOI: 10.1373/clinchem.2006.076851

Field-Weighted Citation Impact: 18.73