Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

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Authors

Anita Y. H. Lee · Merck & Co., Inc., Rahway, NJ, USA (United States)

Nathan A. Yates · Merck & Co., Inc., Rahway, NJ, USA (United States)

Marina Ichetovkin · Institute for Atherosclerosis Research

Ekaterina G. Deyanova · Merck & Co., Inc., Rahway, NJ, USA (United States)

Katie Southwick · Merck & Co., Inc., Rahway, NJ, USA (United States)

Timothy S. Fisher · Institute for Atherosclerosis Research

Abstract

The LC-SRM method provides a new technique for measuring the enrichment of proteins labeled with stable isotopes. LC-SRM is amenable to a multiplexed format to provide a relatively rapid and inexpensive means to measure turnover of multiple proteins simultaneously.

Topics & Keywords

Metabolomics and Mass Spectrometry Studies Advanced Proteomics Techniques and Applications Mass Spectrometry Techniques and Applications

Publication Details

Published in: Clinical Chemistry

Volume 58, Issue 3, pp. 619-627

DOI: 10.1373/clinchem.2011.172429

Field-Weighted Citation Impact: 1.05

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Measurement of Fractional Synthetic Rates of Multiple Protein Analytes by Triple Quadrupole Mass Spectrometry

Authors

Abstract

Topics & Keywords

Publication Details