<i>C9orf72</i> promoter hypermethylation is neuroprotective

201571 citationsJournal Articlebronze Open Access

Authors

Corey T. McMillan · Pennsylvania Academic Library Consortium

Jenny Russ · Pennsylvania Academic Library Consortium

Elisabeth McCarty Wood · Pennsylvania Academic Library Consortium

David J. Irwin · Pennsylvania Academic Library Consortium

Murray Grossman · Pennsylvania Academic Library Consortium

Leo McCluskey · Pennsylvania Academic Library Consortium

Lauren Elman

Abstract

These cross-sectional and longitudinal neuroimaging studies, along with neuropathologic validation studies, provide converging evidence for neuroprotective properties of C9orf72 promoter hypermethylation. These findings converge with prior postmortem studies suggesting that C9orf72 promoter hypermethylation may be a neuroprotective target for drug discovery.

Topics & Keywords

Epigenetics and DNA Methylation Cancer-related gene regulation Genetics and Neurodevelopmental Disorders

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Neurology

Volume 84, Issue 16, pp. 1622-1630

DOI: 10.1212/wnl.0000000000001495

Field-Weighted Citation Impact: 4.97