Effect of Botulinum Toxin in the Treatment of Drooling: A Controlled Clinical Trial

2004201 citationsJournal Articlegreen Open Access

Authors

Peter H. Jongerius · Radboud University Medical Center

Frank J. A. van den Hoogen · Radboud University Medical Center

Jacques van Limbeek · Sint Maartenskliniek

F.J.M. Gabreëls · Radboud University Medical Center

Karen van Hulst · Radboud University Medical Center

Jan J. Rotteveel · Radboud University Nijmegen

Abstract

During scopolamine application as well as after intraglandular BoNT injections, a clinically relevant reduction in drooling was achieved in children with CP, demonstrating maximum effect 2 to 8 weeks after injections. This is the first controlled clinical trial that confirmed a significant effect of BoNT injections in the treatment of drooling. General anesthesia was needed for all children. BoNT injections show fewer and less serious side effects than transdermal scopolamine treatment.

Topics & Keywords

Botulinum Toxin and Related Neurological Disorders Parkinson's Disease Mechanisms and Treatments Sympathectomy and Hyperhidrosis Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PEDIATRICS

Volume 114, Issue 3, pp. 620-627

DOI: 10.1542/peds.2003-1104-l

Field-Weighted Citation Impact: 7.28