AP-1 and NF-kB Regulation in Rheumatoid Arthritis and Murine Collagen-Induced Arthritis

1998368 citationsJournal Article

Authors

Zuoning Han · University of California, San Diego

D. L. Boyle · University of California, San Diego

Alex Manning · SignalRx Pharmaceuticals (United States)

Gary S. Firestein · University of California, San Diego

Abstract

The DNA binding activity of AP-1 and NF-kappaB are markedly increased in both CIA and RA. In CIA, activation of AP-1 and NF-kappaB precede both clinical arthritis and metalloproteinase gene expression. NF-kappaB expression correlated better than AP-1 with metalloproteinase expression.

Topics & Keywords

NF-κB Signaling Pathways Cytokine Signaling Pathways and Interactions Rheumatoid Arthritis Research and Therapies

Publication Details

Published in: Autoimmunity

Volume 28, Issue 4, pp. 197-208

DOI: 10.3109/08916939808995367

Field-Weighted Citation Impact: 5.06

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AP-1 and NF-kB Regulation in Rheumatoid Arthritis and Murine Collagen-Induced Arthritis

Authors

Abstract

Topics & Keywords

Publication Details