GC-Content Evolution in Mammalian Genomes: The Biased Gene Conversion Hypothesis

2001484 citationsJournal Articlebronze Open Access

Authors

Nicolas Galtier · Centre National de la Recherche Scientifique

Gwenaël Piganeau · Centre National de la Recherche Scientifique

D Mouchiroud · Centre National de la Recherche Scientifique

Laurent Duret · Université Claude Bernard Lyon 1

Abstract

BASE composition is spatially structured in mammalian genomes. From sodium chloride centrifugation experiments, Bernardi et al . ([1985][1]) defined three major classes of genomic fragments with low, median, and high GC content, respectively, and called them isochores. This discrete description now

Topics & Keywords

RNA and protein synthesis mechanisms Genomics and Phylogenetic Studies RNA modifications and cancer

Publication Details

Published in: Genetics

Volume 159, Issue 2, pp. 907-911

DOI: 10.1093/genetics/159.2.907

Field-Weighted Citation Impact: 4.62

Command Palette

GC-Content Evolution in Mammalian Genomes: The Biased Gene Conversion Hypothesis

Authors

Abstract

Topics & Keywords

Publication Details