PhosphinooxazolinesA New Class of Versatile, Modular P,N<i>-</i>Ligands for Asymmetric Catalysis

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Authors

Abstract

Chiral phosphinooxazolines (PHOX ligands), which coordinate to a metal center with a N- and a P-atom, allow effective enantiocontrol in a variety of metal-catalyzed reactions. They are readily synthesized, and because of their modular structure, the steric and electronic properties can be tailored for a specific application by variation of the oxazoline ring, the backbone, and the phosphine moiety.

Topics & Keywords

Asymmetric Hydrogenation and Catalysis Asymmetric Synthesis and Catalysis Synthesis and Catalytic Reactions

UN Sustainable Development Goals

Clean water and sanitation

Publication Details

Published in: Accounts of Chemical Research

Volume 33, Issue 6, pp. 336-345

DOI: 10.1021/ar9900865

Field-Weighted Citation Impact: 45.77