Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis

2002846 citationsJournal Articlebronze Open Access

Authors

Dan C. Sorescu · Emory University

Daiana Weiss · Emory University

Bernard Lassègue · Emory University

Roza E. Clempus · Emory University

Katalin Szöcs · Emory University

George P. Sorescu · Emory University

Liisa Valppu · Emory University

Abstract

Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary atherosclerotic disease.

Topics & Keywords

Nitric Oxide and Endothelin Effects Neutrophil, Myeloperoxidase and Oxidative Mechanisms Atherosclerosis and Cardiovascular Diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation

Volume 105, Issue 12, pp. 1429-1435

DOI: 10.1161/01.cir.0000012917.74432.66

Field-Weighted Citation Impact: 26.70