Risk of adverse events among older adults following co-prescription of clarithromycin and statins not metabolized by cytochrome P450 3A4

201471 citationsJournal Articlegold Open Access

Authors

Daniel Q. Li · Western University

Richard Kim · Western University

Eric McArthur · Western University

Jamie L Fleet · Western University

David G. Bailey · Western University

David N. Juurlink · Western University

Salimah Z. Shariff ·

Abstract

Among older adults taking a statin not metabolized by CYP3A4, co-prescription of clarithromycin versus azithromycin was associated with a modest but statistically significant increase in the 30-day absolute risk of adverse outcomes.

Topics & Keywords

Pharmacological Effects and Toxicity Studies Pharmacogenetics and Drug Metabolism Pharmaceutical Practices and Patient Outcomes

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Canadian Medical Association Journal

Volume 187, Issue 3, pp. 174-180

DOI: 10.1503/cmaj.140950

Field-Weighted Citation Impact: 12.14