Targeting the Internal Epitope of Prostate-Specific Membrane Antigen with <sup>89</sup>Zr-7E11 Immuno-PET

201159 citationsJournal Articlebronze Open Access

Authors

Alessandro Ruggiero · Memorial Sloan Kettering Cancer Center

Jason P. Holland · Emory Healthcare

Tvrtko Hudolin · Memorial Sloan Kettering Cancer Center

Larissa Shenker · Memorial Sloan Kettering Cancer Center

Anna Koulova · Memorial Sloan Kettering Cancer Center

Neil H. Bander · Emory University

Jason S. Lewis

Abstract

These findings suggest that (89)Zr-DFO-7E11 displays high tumor-to-background tissue contrast in immuno-PET and can be used as a tool to monitor and quantify, with high specificity, tumor response in PSMA-positive prostate cancer.

Topics & Keywords

Radiopharmaceutical Chemistry and Applications Peptidase Inhibition and Analysis Prostate Cancer Treatment and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Nuclear Medicine

Volume 52, Issue 10, pp. 1608-1615

DOI: 10.2967/jnumed.111.092098

Field-Weighted Citation Impact: 7.84