CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

2014369 citationsJournal Articlebronze Open Access

Authors

Lídia Robert · Fred Hutch Cancer Center

Jennifer Tsoi · Adaptive Biotechnologies (United States)

Xiaoyan Wang · Adaptive Biotechnologies (United States)

Ryan Emerson · Adaptive Biotechnologies (United States)

Blanca Homet · Adaptive Biotechnologies (United States)

Thinle Chodon · Fred Hutch Cancer Center

Stephen Mok

Abstract

CTLA4 blockade with tremelimumab diversifies the peripheral T-cell pool, representing a pharmacodynamic effect of how this class of antibodies modulates the human immune system.

Topics & Keywords

Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology Immune Cell Function and Interaction

Publication Details

Published in: Clinical Cancer Research

Volume 20, Issue 9, pp. 2424-2432

DOI: 10.1158/1078-0432.ccr-13-2648

Field-Weighted Citation Impact: 13.12

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CTLA4 Blockade Broadens the Peripheral T-Cell Receptor Repertoire

Authors

Abstract

Topics & Keywords

Publication Details