Genome Sequencing and Analysis of BCG Vaccine Strains

2013101 citationsJournal Articlegold Open Access

Authors

Wen Zhang · National Institute for Communicable Disease Control and Prevention

Yuanyuan Zhang · National Institute for Communicable Disease Control and Prevention

Huajun Zheng · Chinese National Human Genome Center at Shanghai

Yuanlong Pan · Institute of Microbiology

Haican Liu · National Institute for Communicable Disease Control and Prevention

Pengcheng Du · National Institute for Communicable Disease Control and Prevention

Abstract

Our results revealed the cause of BCG vaccine strain protection variability at the genome level and supported the hypothesis that the restoration of lost BCG Tokyo epitopes is a useful future vaccine development strategy. Furthermore, these detailed BCG vaccine genome investigation results will be useful in microbial genetics, microbial engineering and other research fields.

Topics & Keywords

Tuberculosis Research and Epidemiology Immunodeficiency and Autoimmune Disorders Immune responses and vaccinations

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 8, Issue 8, pp. e71243-e71243

DOI: 10.1371/journal.pone.0071243

Field-Weighted Citation Impact: 5.21