A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample

2011311 citationsJournal Articlegold Open Access

Authors

Ma’en Obeidat · Nottingham Biomedical Research Centre

Louise V. Wain · University of Leicester

Nick Shrine · University of Leicester

Noor Kalsheker · Queen's Medical Centre

María Soler Artigas · University of Leicester

Emmanouela Repapi · Ludwig Cancer Research

Paul R. Burton ·

Abstract

Polymorphisms spanning previously associated lung function genes did not show strong evidence for association with lung function measures in the SpiroMeta consortium population. Common SERPINA1 polymorphisms may affect FEV(1) among smokers in the general population.

Topics & Keywords

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Pediatric health and respiratory diseases

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 6, Issue 5, pp. e19382-e19382

DOI: 10.1371/journal.pone.0019382

Field-Weighted Citation Impact: 26.43