A population-based study of the drug interaction between proton pump inhibitors and clopidogrel

2009764 citationsJournal Articlegold Open Access

Authors

David N. Juurlink · Sunnybrook Health Science Centre

Tara Gomes · Institute for Clinical Evaluative Sciences

Dennis T. Ko · Health Sciences Centre

Paul E. Szmitko · University of Toronto

Peter C. Austin · University of Toronto

Jack V. Tu · Sunnybrook Health Science Centre

David Henry

Abstract

Among patients receiving clopidogrel following acute myocardial infarction, concomitant therapy with proton pump inhibitors other than pantoprazole was associated with a loss of the beneficial effects of clopidogrel and an increased risk of reinfarction.

Topics & Keywords

Antiplatelet Therapy and Cardiovascular Diseases Gastroesophageal reflux and treatments Synthesis of β-Lactam Compounds

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Canadian Medical Association Journal

Volume 180, Issue 7, pp. 713-718

DOI: 10.1503/cmaj.082001

Field-Weighted Citation Impact: 83.44