Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

2013116 citationsJournal Articlegold Open Access

Authors

Julie T. Marchesan · University of Michigan–Ann Arbor

Elizabeth Ann Gerow · University of Michigan–Ann Arbor

Riley Schaff · University of Michigan–Ann Arbor

Andrei D. Taut · University of Michigan–Ann Arbor

Seung‐Yun Shin · University of Michigan–Ann Arbor

James V. Sugai · University of Michigan–Ann Arbor

David Brand

Abstract

Chronic P. gingivalis oral infection prior to arthritis induction increases the immune system activation favoring Th17 cell responses, and ultimately accelerating arthritis development. These results suggest that chronic oral infection may influence RA development mainly through activation of Th17-related pathways.

Topics & Keywords

Oral microbiology and periodontitis research Oral Health Pathology and Treatment Oral and gingival health research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Arthritis Research & Therapy

Volume 15, Issue 6, pp. R186-R186

DOI: 10.1186/ar4376

Field-Weighted Citation Impact: 6.70