Pharmacokinetic evaluation of recombinant, activated factor VII in patients with inherited factor VII deficiency.

200160 citationsJournal Article

Authors

Mauro Berrettini · National Hemophilia Foundation

Giuliano Mariani

Abstract

These findings suggest that the kinetics of rFVIIa are not dose-dependent. In the absence of FVII, the changes of VdArea and CL may be in agreement with a mechanism of competition between FVII and rFVIIa for tissue factor binding.

Topics & Keywords

Hemophilia Treatment and Research Blood Coagulation and Thrombosis Mechanisms Hemostasis and retained surgical items

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PubMed

Volume 86, Issue 6, pp. 640-5

Field-Weighted Citation Impact: 1.46