Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

2009383 citationsJournal Articlebronze Open Access

Authors

Toshiro Migita · Boston Children's Hospital

Stacey Ruiz · Brigham and Women's Hospital

A Fornari · Harvard University

Michelangelo Fiorentino · Brigham and Women's Hospital

Carmen Priolo · Dana-Farber Cancer Institute

Giorgia Zadra · Harvard University

Fumika Inazuka ·

Abstract

These observations suggest that FASN can act as a prostate cancer oncogene in the presence of AR and that FASN exerts its oncogenic effect by inhibiting the intrinsic pathway of apoptosis.

Topics & Keywords

Cancer, Lipids, and Metabolism Prostate Cancer Treatment and Research Cholangiocarcinoma and Gallbladder Cancer Studies

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: JNCI Journal of the National Cancer Institute

Volume 101, Issue 7, pp. 519-532

DOI: 10.1093/jnci/djp030

Field-Weighted Citation Impact: 10.11