Construction of an Immunotoxin, D2C7-(scdsFv)-PE38KDEL, Targeting EGFRwt and EGFRvIII for Brain Tumor Therapy

201366 citationsJournal Article

Authors

Vidyalakshmi Chandramohan · Center for Cancer Research

Xuhui Bao · Duke University Hospital

Stephen T. Keir · Duke University Hospital

Charles N. Pegram · Huashan Hospital

Scott E. Szafranski · Huashan Hospital

Hailan Piao · Fudan University

Carol J. Wikstrand ·

Abstract

In preclinical studies, the D2C7-(scdsFv)-PE38KDEL immunotoxin exhibited significant potential for treating brain tumors expressing EGFRwt, EGFRvIII, or both.

Topics & Keywords

Toxin Mechanisms and Immunotoxins Monoclonal and Polyclonal Antibodies Research Neuroblastoma Research and Treatments

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 19, Issue 17, pp. 4717-4727

DOI: 10.1158/1078-0432.ccr-12-3891

Field-Weighted Citation Impact: 3.29