Efficient Chemotherapy of Rat Glioblastoma Using Doxorubicin-Loaded PLGA Nanoparticles with Different Stabilizers

2011160 citationsJournal Articlegold Open Access

Authors

Stefanie Wohlfart · Goethe University Frankfurt

A. S. Khalansky · Research Institute of Human Morphology

Svetlana Gelperina · Nanosystem (Russia)

Olga Maksimenko · Nanosystem (Russia)

Christian Bernreuther · University Medical Center Hamburg-Eppendorf

Markus Glatzel · University Medical Center Hamburg-Eppendorf

Jörg Kreuter

Abstract

The results reveal a considerable anti-tumour effect of the doxorubicin-loaded nanoparticles. The overall best results were observed for Dox-Lecithin-PLGA/HSA. These data demonstrate that the poloxamer 188-coated PLGA nanoparticles enable delivery of doxorubicin across the blood-brain barrier in the therapeutically effective concentrations.

Topics & Keywords

Nanoparticle-Based Drug Delivery Nanoplatforms for cancer theranostics RNA Interference and Gene Delivery

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 6, Issue 5, pp. e19121-e19121

DOI: 10.1371/journal.pone.0019121

Field-Weighted Citation Impact: 5.93