Expression of mTOR signaling pathway markers in prostate cancer progression

2006183 citationsJournal Article

Authors

Celeste L. Kremer · University of Arizona

Rob R. Klein · University of Arizona

Jenny Mendelson · University of Arizona

Walden Browne · University of Arizona

Linda K. Samadzedeh · Ventana Research Corporation (United States)

Kristie A. Vanpatten · Ventana Research Corporation (United States)

Lindsey Highstrom

Abstract

Results suggest that 4E-BP1 overexpression is strongly associated with prostate cancer, especially when combined with PTEN and mTOR expression data. Hierarchical clustering analysis utilizing PTEN, mTOR, and 4E-BP1 separated normal from cancer cell populations in most cases.

Topics & Keywords

PI3K/AKT/mTOR signaling in cancer Prostate Cancer Treatment and Research Cancer, Lipids, and Metabolism

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: The Prostate

Volume 66, Issue 11, pp. 1203-1212

DOI: 10.1002/pros.20410

Field-Weighted Citation Impact: 4.60