Diesel Exhaust Inhalation Causes Vascular Dysfunction and Impaired Endogenous Fibrinolysis

2005641 citationsJournal Articlebronze Open Access

Authors

Nicholas L. Mills · University of Edinburgh

Håkan Törnqvist

Simon D. Robinson · University of Edinburgh

Manuel González · University of Edinburgh

Kareen Darnley · University of Edinburgh

William MacNee · University of Edinburgh

Nicholas A. Boon · University of Edinburgh

Abstract

At levels encountered in an urban environment, inhalation of dilute diesel exhaust impairs 2 important and complementary aspects of vascular function in humans: the regulation of vascular tone and endogenous fibrinolysis. These important findings provide a potential mechanism that links air pollution to the pathogenesis of atherothrombosis and acute myocardial infarction.

Topics & Keywords

Air Quality and Health Impacts Climate Change and Health Impacts Vehicle emissions and performance

UN Sustainable Development Goals

Sustainable cities and communities

Publication Details

Published in: Circulation

Volume 112, Issue 25, pp. 3930-3936

DOI: 10.1161/circulationaha.105.588962

Field-Weighted Citation Impact: 21.68