High-Risk Ovarian Cancer Based on 126-Gene Expression Signature Is Uniquely Characterized by Downregulation of Antigen Presentation Pathway

2012197 citationsJournal Articlebronze Open Access

Authors

Kosuke Yoshihara · Kagoshima City Hospital

Tatsuhiko Tsunoda · Jichi Medical University

Daichi Shigemizu · Kagoshima City Hospital

Hiroyuki Fujiwara · Jichi Medical University

Masayuki Hatae · Niigata University

Hisaya Fujiwara · Yokohama City University Hospital

Hideaki Masuzaki

Abstract

This risk classification based on the 126-gene expression signature is an accurate predictor of clinical outcome in patients with advanced stage high-grade serous ovarian cancer and has the potential to develop new therapeutic strategies for high-grade serous ovarian cancer patients.

Topics & Keywords

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 18, Issue 5, pp. 1374-1385

DOI: 10.1158/1078-0432.ccr-11-2725

Field-Weighted Citation Impact: 4.76