Canine status epilepticus treated with fosphenytoin: A proof of principle study

201520 citationsJournal Articlegreen Open Access

Authors

Edward E. Patterson · University of Minnesota Medical Center

Ilo E. Leppik · University of Minnesota

Lisa D. Coles · University of Minnesota

Michael Podell · University of Chicago

Charles H. Vite · University of Pennsylvania

William W. Bush · Society for Imaging Informatics in Medicine

James C. Cloyd

Abstract

This proof of concept study provides the first evidence that FOS is tolerated and effective in canine SE at PHT concentrations clinically relevant for human SE. Furthermore, naturally occurring CSE can be utilized as a translational platform for future studies of novel SE compounds.

Topics & Keywords

Epilepsy research and treatment Pharmacological Effects and Toxicity Studies Drug Transport and Resistance Mechanisms

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Epilepsia

Volume 56, Issue 6, pp. 882-887

DOI: 10.1111/epi.12994

Field-Weighted Citation Impact: 2.31