A Novel Way to Grow Hemozoin-Like Crystals In Vitro and Its Use to Screen for Hemozoin Inhibiting Antimalarial Compounds

201224 citationsJournal Articlegold Open Access

Authors

Vincent Thomas

Ana Góis · Instituto de Medicina Molecular João Lobo Antunes

Bruce Ritts

Peter Burke · Steris (United States)

Thomas Hänscheid · Instituto de Medicina Molecular João Lobo Antunes

Gerald McDonnell · Steris (United Kingdom)

Abstract

The described HLC assay is simple and easy to perform and may have the potential to be used as an additional tool to screen antimalarial drugs for their hemozoin inhibiting activity. As already described by others, drugs that inhibit hemozoin crystal formation have also the potential to inhibit misfolded proteins assemblies formation.

Topics & Keywords

Prion Diseases and Protein Misfolding HIV Research and Treatment Malaria Research and Control

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: PLoS ONE

Volume 7, Issue 7, pp. e41006-e41006

DOI: 10.1371/journal.pone.0041006

Field-Weighted Citation Impact: 1.05