Tumor Hypoxia Predicts Biochemical Failure following Radiotherapy for Clinically Localized Prostate Cancer

2012288 citationsJournal Article

Authors

Michael Milosevic · University of Toronto

Padraig Warde · University of Toronto

Cynthia Ménard · Princess Margaret Cancer Centre

Peter Chung · Princess Margaret Cancer Centre

Ants Toi · University of Toronto

Adrian Ishkanian · Princess Margaret Cancer Centre

Michael McLean ·

Abstract

This is the largest clinical study of prostate cancer hypoxia with direct measurement of tumor oxygen levels. It shows that hypoxia is associated with early biochemical relapse after radiotherapy and also with local recurrence in the prostate gland.

Topics & Keywords

Cancer, Hypoxia, and Metabolism Hepatocellular Carcinoma Treatment and Prognosis Prostate Cancer Treatment and Research

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Clinical Cancer Research

Volume 18, Issue 7, pp. 2108-2114

DOI: 10.1158/1078-0432.ccr-11-2711

Field-Weighted Citation Impact: 7.15