Increased numbers of CD5+CD19+CD1dhighIL-10+ Bregs, CD4+Foxp3+ Tregs, CD4+CXCR5+Foxp3+ follicular regulatory T (TFR) cells in CHB or CHC patients

201467 citationsJournal Articlegold Open Access

Authors

Li Wang · First Hospital of Jilin University

Jinpeng Qiu · First Hospital of Jilin University

Lei Yu · Fourth Affiliated Hospital of Harbin Medical University

Xiaoli Hu · Heilongjiang Provincial Hospital

Pingwei Zhao · Jilin University

Yanfang Jiang · First Hospital of Jilin University

Abstract

Increased numbers of circulating IL-10+ Bregs and TFR cells are associated with poor virus eradication and liver injury in CHB and CHC patients. Furthermore, the levels of serum IL-10 is associated with the hepatic flares.

Topics & Keywords

Hepatitis B Virus Studies Immunotherapy and Immune Responses Immune Cell Function and Interaction

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Journal of Translational Medicine

Volume 12, Issue 1, pp. 251-251

DOI: 10.1186/s12967-014-0251-9

Field-Weighted Citation Impact: 3.22