The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H <sup>+</sup> -ATPase Assembly in Murine Cardiomyocytes

2010297 citationsJournal Articlebronze Open Access

Authors

Kenichiro Kinouchi · Doshisha Women's College of Liberal Arts

Atsuhiro Ichihara · Japan Science and Technology Agency

Motoaki Sano · Osaka University

Ge-Hong Sun-Wada · Osaka University

Yoh Wada · Osaka University

Asako Kurauchi‐Mito · Food Research Institute

Kanako Bokuda ·

Abstract

Genetic ablation of Atp6ap2 created a loss-of-function model for V-ATPase. The gene product of ATP6AP2 is considered to act as in 2 ways: (1) as (P)RR, exerting a RAS-related function; and (2) as the V-ATPase-associated protein, exerting a non-RAS-related function that is essential for cell survival.

Topics & Keywords

ATP Synthase and ATPases Research Renin-Angiotensin System Studies Hormonal Regulation and Hypertension

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Circulation Research

Volume 107, Issue 1, pp. 30-34

DOI: 10.1161/circresaha.110.224667

Field-Weighted Citation Impact: 10.39