Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

2010656 citationsJournal Articlebronze Open Access

Authors

Isotta Chimenti · Johns Hopkins University

Rachel Smith · Johns Hopkins University

Tao‐Sheng Li · Johns Hopkins University

Gary Gerstenblith · Johns Hopkins University

Elisa Messina · Johns Hopkins University

Alessandro Giacomello · Johns Hopkins University

Eduardo Marbán ·

Abstract

Together with their spontaneous commitment to cardiac and angiogenic differentiation, transplanted CDCs serve as "role models," recruiting endogenous regeneration and improving tissue resistance to ischemic stress. The contribution of the role model effect rivals or exceeds that of direct regeneration.

Topics & Keywords

Tissue Engineering and Regenerative Medicine Electrospun Nanofibers in Biomedical Applications Congenital heart defects research

Publication Details

Published in: Circulation Research

Volume 106, Issue 5, pp. 971-980

DOI: 10.1161/circresaha.109.210682

Field-Weighted Citation Impact: 52.28

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Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice

Authors

Abstract

Topics & Keywords

Publication Details