NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

2012266 citationsJournal Articlebronze Open Access

Authors

Wing‐Kin Syn · Foundation for Liver Research

Kolade M. Agboola · Duke University

Marzena Swiderska · Duke University

Gregory A. Michelotti · Duke University

Evaggelia Liaskou · University of Birmingham

Herbert Pang · Duke University

Guanhua Xie ·

Abstract

Hepatic NKT cells drive production of OPN and Hh ligands that promote fibrogenesis during NASH. Associated increases in plasma levels of OPN may provide a biomarker of NASH fibrosis.

Topics & Keywords

Liver Disease Diagnosis and Treatment Pancreatic function and diabetes Endoplasmic Reticulum Stress and Disease

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Gut

Volume 61, Issue 9, pp. 1323-1329

DOI: 10.1136/gutjnl-2011-301857

Field-Weighted Citation Impact: 16.04