Regulatory Mechanisms for Adipose Tissue M1 and M2 Macrophages in Diet-Induced Obese Mice

2009712 citationsJournal Articlehybrid Open Access

Authors

Shiho Fujisaka · The University of Tokyo

Isao Usui · The University of Tokyo

Agussalim Bukhari · The University of Tokyo

Masashi Ikutani

Takeshi Oya · University of Toyama

Yukiko Kanatani · The University of Tokyo

Koichi Tsuneyama · University of Toyama

Abstract

M1 and M2 ATMs constitute different subsets of macrophages. Insulin resistance is associated with both the number of M1 macrophages and the M1-to-M2 ratio. The increased expression of IL-10 after an HFD might be involved in the increased recruitment of M2 macrophages.

Topics & Keywords

Adipokines, Inflammation, and Metabolic Diseases Adipose Tissue and Metabolism Immune cells in cancer

UN Sustainable Development Goals

Good health and well-being

Publication Details

Published in: Diabetes

Volume 58, Issue 11, pp. 2574-2582

DOI: 10.2337/db08-1475

Field-Weighted Citation Impact: 15.01